Neuron specific reduction in CuZnSOD is not sufficient to initiate a full sarcopenia phenotype
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چکیده
منابع مشابه
Neuron specific reduction in CuZnSOD is not sufficient to initiate a full sarcopenia phenotype
Our previous studies showed that adult (8 month) mice lacking CuZn-superoxide dismutase (CuZnSOD, Sod1KO mice) have neuromuscular changes resulting in dramatic accelerated muscle atrophy and weakness that mimics age-related sarcopenia. We have further shown that loss of CuZnSOD targeted to skeletal muscle alone results in only mild weakness and no muscle atrophy. In this study, we targeted dele...
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ژورنال
عنوان ژورنال: Redox Biology
سال: 2015
ISSN: 2213-2317
DOI: 10.1016/j.redox.2015.04.005